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近五年科研成果介绍
发布日期:2023-05-22 作者:基础医学院 浏览次数:
       近五年来,基础医学院共获得省级以上教学、科研奖励6项;国家自然科学基金及省部级以上科研项目39项;科研总经费634.2万;发表科研论文260余篇,其中SCI收录论文75篇、CSCD收录论文62篇主编、参编国家级“十三五”规划教材 45 部,卫生部规划教材33部,卫生部医学视听教材2部。

  学院注重智力引进、学术交流和青年教师培养,与丹麦哥本哈根大学合作建立了我校第一个国际性科研合作平台“脊髓损伤与修复研究室”,聘请英国医学科学院和英国皇家学会两院院士Ian David Hickson院士、哥本哈根大学的Hans Hultborn院士为特聘教授,指导学科建设和发展,先后有4名教师到哥本哈根大学攻读博士学位或研修,河北省神经损伤与修复重点实验室已获批立项建设。同时,学院每年支持30余人次教师外出参加各类学术交流或到国内大学进行研修、培训。有河北省基础医学实验教学示范中心、河北省机能实验学实验教学示范中心等实践教学资源。有河北省病理学与病理生理学重点学科、河北省病原生物学重点学科、河北省人体解剖与组织胚胎学重点发展学科;有承德医学院院士工作站、承德医学院外国院士工作站等研究平台;有10个校级研究室。实验室总面积2810多平方米,仪器设备4745台(件),总价值4185万元。为研究生学习和科研提供了有力支撑。


   

1   2018-2022年省级教学科研获奖情况

成果名称

奖项名称及等级

获奖教师姓名(排名)

年度

抑制人绒毛膜癌增殖侵袭及其精准治疗的研究与应用

河北省科技进步二等奖

李玉红(1

2022-3

穿山龙对 CIA 鼠的治疗作用及其机制研究

河北省科技进步三等奖

郭亚春(2

2019-1

多途径系列化大学生防艾健康教育的创新与实践

河北省教学成果二等奖

杜少杰(1

李玉红(4

2019-12

以岗位胜任力为导向,构建四位一体的感染性疾病学整合课程体系

河北省教学成果二等奖

刘金霞(1),郭亚春(2),邴玉艳(3),王丽娜(4

2019-12

地方院校基于卓越医生教育的中医学人才培养模式改革实践

河北省教学成果一等奖

李玉红(2

2019-12

细胞因子与心肌损伤的基础与临床研究

河北省科技进步三等奖

于海荣(2

2020-4

补肾中药何首乌饮调控衰老大鼠生殖功能机制研究

科学技术进步奖二等奖

王小杰(5

2021-1

2   2018-2022年省级及以上科研立项

序号

项目

负责人

项目名称

项目来源

立项年度

项目起止年月

合同经费(万元)

1

谢广成

基于“异病同治”的扶正解毒方治疗不同呼吸道病毒所致肺炎的效应机制研究——不同呼吸道病毒所致肺炎核心病机的科学内涵研究

国家重点研发计划“中医药现代化”专项

2022

202212-202512

50

2

任立群

DNA单链断裂修复途径中抑制神经退行性疾病的靶向基因研究

科技部高端外国专家引进计划项目

2022

202201-202212

13

3

任立群

可降解生物医用金属

河北省自然基金创新群体项目

2022

202201-202212

50

4

郭文平

河北省环首都地区婢传人兽共患立克次氏体的生态学研究

 

河北省自然科学基金

2022

202201-202512

10

5

程玉

RNF19介导LATS1泛素化降解并抑制Hippo信号通路促进胃癌的功能机制研究

河北省自然科学基金

2022

202201-202512

6

6

于永洲

基于膜片钳技术探讨钩滕透脑成分抗高热惊厥作用的分子机制

河北省自然科学基金中医药联合基金培育项目

2022

202201-202512

 

 

10

7

于大永

基于PI3K/Akt/mTOR和p38 MAPK信号通路探究豆瓣绿抗肿瘤作用机理

河北省自然科学基金中医药联合基金培育项目

2022

202201-2025212

 

10

8

刘镭

臭椿酮调控p23/HSP90/mTOR/SLC7A11通路诱导自噬依赖性铁死亡抑制非小细胞肺癌生长

河北省自然科学基金

2021

202101-202312

10

9

苗浩

C/EBP-β过表达逆转人肝癌HepG2细胞索拉非尼耐药的机制研究

河北省自然科学基金

2021

202105-202312

6

10

付秀美

施万细胞样细胞来源的NGF通过PI3K/Akt信号通路促进周围神经再生修复的分子机制

河北省自然科学基金

2021

202107-202412

10

11

高亚贤

TL1A通过与ELAVL1互作促进胃癌增殖和迁移的机制研究

河北省自然科学基金

2021

202105-202312

10

12

侯志平

循环外泌体miRNA在结直肠癌早期诊断中的应用

河北省科技厅专项

2021

202105-202312

7

13

沈春阳

河北卤虫种质资源和遗传多样性研究

河北省科技厅专项

2021

202101-202112

20

14

于永洲

钩藤抗高热惊厥作用的脑内药效物质基础研究

河北省科技厅专项

2021

202101-202412

12

15

郭文平

河北口岸输入性重要传染病及病媒生物传入风险评估与防控体系建设研究

河北省科技厅专项

2021

202101-202412

15

16

赵长祺

生命科学探索与教育科普示范基地提升建设

河北省科技厅科普专项

2021

202101-202412

20

17

王会玲

免疫检查点受体CD200R介导小胶质细胞异常吞噬的分子机制研究

河北省人力资源和社会保障厅

2021

202109-202409

1

18

任立群

可再生自修复自组装纺丝二维复合薄膜及其过滤防护机制研究

国家自然科学基金

2020

202001-202212

15

19

赵娟

技术创新引导专项科技工作会商基础医学学科专项

河北省科

技厅

2020

202009-202212

130

20

李玉红

慢性应激经β2-AR/plexinA1介导细胞EMT和血管生成促进胃癌恶性进展的机制研究

河北省自

然科学基

2020

202001-202212

10

21

赵娟

应用基因芯片技术研究Urantide调控Wnt/β-catenin信号通路改善动脉粥样硬化的作用机制

河北省自

然科学基

2020

202001-202412

10

22

杨秀安

INTS1引起罕见病NDCAGF 综合征认知障碍表型的分子机制研究

河北省自然科学基金

2020

202009-202312

10

23

沈春阳

异纽目纽形动物线粒体基因组与系统发育研究

河北省自然科学基金

2020

202001-202312

6

24

郭文平

河北省蜱媒人兽共患立克次氏体的自然疫源地调查

河北省教育厅青年拔尖人才项目

2020

202001-202312

9

25

杨雪

基于光谱监测的多模式超声加碱强化酪蛋白酶解反应研究

河北省教育厅青年拔尖人才项目

2019

201901-202112

9

26

任立群

承德医学院院士工作站建设专项

河北省科

技计划项

2019

201901-202012

35

27

任立群

基因组不稳定性与疾病的相关研究

河北省科技厅专项

2019

201901-202012

30

28

许倩

miR351调控线粒体自噬作为非小细胞肺癌顺铂耐药诊断的新技术研究

河北省科技计划项目

2019

201906-202106

5

29

杨雪

多频S型超声预处理对大分子多肽功能活性的影响及其机理研究

河北省自然科学基金

2019

201901-202112

6

30

鲁艳杰

焦虑情绪对胃癌细胞休眠复苏和侵袭转移的影响及其机制的研究

河北省自然科学基金

2019

201901-202112

6

31

任立群

脊髓损伤后多巴胺受体在痉挛发生发展中的作用

河北省人力资源和社会保障厅

2019

201901-202112

1

32

周晓慧

丹皮酚改善糖尿病心肌病机制及作用靶点研究

河北省自

然科学基

2018

201801-202012

6

33

赵亮

心肌肥厚易感心律失常的新机制:STAT3/miR-27a/Hoxa10调控心肌重构

河北省自然科学基金

2018

201801-202012

4

34

谢广成

TLR2募集TLR1TLR6 EV71感染的分子机制研究

河北省自然科学基金

2018

201801-202012

4

35

郭文平

陕西省蜱源性立克次氏体目细菌的遗传多样性及病原体分离

国家自然科学基金

2017

201801-202012

14.2

36

赵亮

心肌肥厚易感心律失常的新机制:STAT3/miR-27a/Hoxa10轴调控心肌电重构

国家自然科学基金

2017

201801-

202012

20

37

谢广成

EV71衣壳蛋白经TLR2/TLR4异源二聚体活化细胞因子反应的研究

国家自然科学基金

2017

201801-202012

20

38

刘镭

臭椿苦酮作用于“EMT-线粒体自噬-氧化应激轴逆转非小细胞肺癌耐药性

国家自然科学基金

2017

201801-202012

19

39

侯志平

miRNA-96-5p/Rho-GTPases/CDC42信号轴在大肠癌侵袭/转移中作用机制研究

河北省人力资源和社会保障厅

2017

201706-202107

5

 

3  2018-2022年代表性论文

序号

论文标题

作者

发表期刊

发表年份及卷(期)页

期刊收录情况

1

Direct effect of RFRP-3 microinjection into the   lateral ventricle on the hypothalamic kisspeptin neurons in ovariectomized   estrogen-primed rats.

程露阳;乔跃兵

Exp Ther Med

2022,23(1):24

SCI

2

CD44 is a prognostic biomarker and correlated with   immune infiltrates in gastric cancer

侯伟岩,纪海茹

BMC Medecine Genomics

2022;15(1):225

SCI

3

Molecular detection of "Candidatus Rickettsia   tarasevichiae" by Loop-mediated Isothermal Amplification (LAMP) of the   ompA gene

薛晶,郭文平

J Microbiol Methods

2022,202:106601

SCI

4

Effects of long noncoding RNA AK093407 on the   biological behavior of colon cancer cells and the underlying mechanism

赵学荣;肖丽君

Combinatorial Chemistry &   High Throughput Screening

2022 Apr 8. Online ahead of   print.

SCI

5

Genetic diversity of Bartonella infection in   residential and field rodents in Hebei, China

菅蕊,郭文平

Front Microbiol

2022,13:1039665

SCI

6

Bone Marrow Mesenchymal Stem Cells (BMSCs)-Triggered   Up-Regulation of miR-1297/NLR Family Pyrin Domain Containing 3 (NLRP3) Facilitates   the Aggressive Proliferation of Lung Cancer Cells via Inducing Inflammatory   Factor Release

梁秀军

JOURNAL OF BIOMATERIALS AND   TISSUE ENGINEERING

2022,12(7):1440-1446

SCI

7

Effect of Microwave Pretreatment on the Antioxidant   Activity and Stability of Enzymatic Products from Milk Protein

杨雪

Foods

2022, 11, 1759.

SCI

8

Uncovering the effects and mechanism of Danggui   Shaoyao San intervention on primary dysmenorrhea by serum metabolomics   approach

李娜,熊辉

Journal of chromatography. B,   Analytical technologies in the biomedical and life sciences

2022,1209:123434.

SCI

9

High-throughput UPLC-Q-TOF-MS/MS coupled with   multivariable data processing approach for the rapid screening and   characterization of chemical constituents and potential bioactive compounds   from Danggui-Shaoyao San

李娜,熊辉

Biomedical chromatography :   BMC

2022,36(9):e5420.

SCI

10

Integrated Serum Pharmacochemistry, Metabolomics, and   Network Pharmacology to Reveal the Material Basis and Mechanism of Danggui   Shaoyao San in the Treatment of Primary Dysmenorrhea

李娜,赵春颖

Frontiers in Pharmacology

2022,13:942955

SCI

11

Disseminated Talaromyces marneffei Infection in a   Non-HIV Infant With a Homozygous Private Variant of RELB

杨秀安

Front Cell Infect Microbiol

11:605589

SCI

12

The complete mitochondrial genome of soft coral   Sinularia penghuensis Ofwegen and Benayahu, 2012 (Octocorallia: Alcyonacea):   the analysis of mitogenome organization and phylogeny

ALIREZA ASEM; 沈春阳

Crustaceana

2022, 95 (5-6): 585-592

SCI

13

Characterization of the complete mitochondrial genome   of Quasilineus sinicus Gibson, 1990 (Nemertea: Heteronemertea) and its   phylogenetic implications

沈春阳;付春正

Mitochondrial DNA Part   B-Resources

2022,7:9, 1749-1751

SCI

14

Exogenous Melatonin Regulates Puberty and the   Hypothalamic GnRH-GnIH System in Female Mice

乔跃兵,杨松鹤(共同通讯)

Brain Sci.

 2022, 12, 1550:1-14

SCI

15

Urantide prevents   CCl4‑induced acute liver injury in rats by regulating the MAPK signalling   pathway

赵娟

Molecular Medicine   Reports

2021,24:688

SCI

16

Urantide alleviates   the symptoms of atherosclerotic rats in vivo and in vitro models through the   JAK2/STAT3 signaling pathway

赵娟

European Journal of   Pharmacology

2021,902:174037

SCI

17

Urantide decreases   hepatic steatosis in rats with experimental atherosclerosis via the   MAPK/Erk/JNK pathway

赵娟

Molecular Medicine   Reports

2021,23:284

SCI

18

Effects of paeonol   on proliferation and collagen synthesis of rat cardiac fibroblasts induced by   aldosterone

杜超

Bangladesh J   Pharmacol

2021(16):42-48

SCI

19

 Effects of Apigenin on the Expression of   LOX-1, Bcl-2, and Bax in Hyperlipidemia Rats

徐倩

Chem. Biodiversity

2021(7)

SCI

20

AnnexinA5 Might   Suppress the Phenotype of Human Gastric Cancer Cells via ERK pathway

李欣

Frontiers in   oncology

2021,11(665105)

SCI

21

miR-373-3p inhibits   epithelial-mesenchymal transition via regulation of TGFβR2 in choriocarcinoma

李玉红

JOURNAL OF   OBSTETRICS AND GYNAECOLOGY RESEARCH

2021,47(7):   3589-3601

SCI

22

Chronic Stress   Activates PlexinA1/VEGFR2-JAK2-STAT3 in Vascular Endothelial Cells to Promote   Angiogenesis in Gastric Cancer

李玉红

Frontiers in   oncology

2021,11:709057

SCI

23

Krüppel-like factor   7 attenuates hippocampal neuronal injury after traumatic brain injury

付秀美

 Neural Regen Res

 2022,17(3):661-672

SCI

24

Disseminated   Talaromyces marneffei Infection in a Non-HIV Infant With a Homozygous Private   Variant of RELB

杨秀安

Front Cell Infect   Microbiol

11:605589

SCI

25

C/EBPβ enhances   efficacy of sorafenib in hepatoblastoma

苗浩

Cell Biol Int

2021,45(9):1897-1905

SCI

26

A rapid juvenile   murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent   hypoxia exacerbates Western diet-induced NASH

周健

Life Sciences

2021,276:119403

SCI

27

MiR-27a-3p/Hoxa10   Axis Regulates Angiotensin II-Induced Cardiomyocyte Hypertrophy by Targeting   Kv4.3 Expression

赵亮

Front Pharmacol

2021,12:680349

SCI

28

Re-clustering and   profiling of digestive system tumors according to microenvironment components

高亚贤

Frontiers in   Oncology

2021,10:607742

SCI

29

Next-generation   sequencing-based identification of EGFR and NOTCH2 complementary mutations in   non-small cell lung cancer. 

刘镭

Oncol Lett.

2021,

22(2):594.

SCI

30

The complete   mitochondrial genome of soft coral Sinularia penghuensis Ofwegen and   Benayahu, 2012 (Octocorallia: Alcyonacea): the analysis of mitogenome   organization and phylogeny

沈春阳

Mitochondrial DNA   Part B-Resources

2021,6(4):1348–1350

SCI

31

First record of the   invasive American Artemia franciscana Kellogg, 1906 (Branchiopoda, Anostraca)   at the South China Sea coast of China

沈春阳

Crustaceana

2021,94(5): 647-650

SCI

32

Prevalence and   clinical characteristics of hospitalized children with community-acquired   Mycoplasma pneumoniae pneumonia during 2017/2018, Chengde, China

谢广成

Medicine

2021, 100(5):e23786

SCI

33

Edible Bird’s Nest   Attenuates Menopause-Related Bone Degeneration in Rats via increased bone   estrogen-receptor expression

侯志平

Chinese Journal Of   Integrative Medicine

2021,

27(4):280-285

SCI

34

Orthohantaviruses   infections in humans and rodents in Baoji, China

郭文平

PLoS Neglected   Tropical Diseases

2020,14(10):e0008778

SCI

35

Extensive genetic   diversity of Anaplasma bovis in ruminants in Xi'an, China

郭文平

Ticks and Tick-Borne   Diseases

2020,11(5):101477

SCI

36

Mosaic genome of   Human Coxsackievirus A4 associated with herpangina and HFMD in Yancheng,   China, 2016 and 2018

郭文平

International   Journal of Infectious Diseases

2020,96:538-540

SCI

37

An adult   co-presented with varicella and herpes zoster caused by varicella zoster   virus genotype J, China: a case report

谢广成

BMC Infectious   Diseases

2020,20(1):454

SCI

38

Global profiling of   the alternative splicing landscape reveals transcriptomic diversity during   the early phase of enterovirus 71 infection

谢广成

Virology

2020,548:213-225

SCI

39

Molecular   Epidemiology and Clinical Features of Haemophilus influenzae among   Hospitalized Children with Community-acquired Pneumonia in Chengde, China

谢广成

Biomedical and   Environmental Sciences

2020,33(8):623-627

SCI

40

Trichinella spiralis   muscle larvae excretory/secretory products trigger apoptosis and S-phase   arrest of the non-small-cell lung cancer line A549

杜娈英

Experimental   Parasitology

2020,218:107983

SCI

41

Melatonin Inhibits   Oxidative Stress and Apoptosis in Cryopreserved Ovarian Tissues via Nrf2/HO-1   Signaling Pathway

杨松鹤

Front Mol Biosci

2020,7:163

SCI

42

Antioxidative effect   of melatonin on cryopreserved ovarian tissue in mice.

杨松鹤

Cryobiology

2020,96:99-105

SCI

43

Inhibitory effect of   dihydromyricetin on the proliferation of JAR cells and its mechanism of   action

李玉红

Oncology letters

2020,20(1):357-363

SCI

44

The peptide compound   urantide regulates collagen metabolism in atherosclerotic rat hearts and   inhibits the JAK2/STAT3 pathway

赵娟

Molecular Medicine   Reports

2020,21(3):1097-1106

SCI

45

Urotensin receptor   antagonist urantide improves atherosclerosis-related

赵娟

Life Sciences

2020,247:117421

SCI

46

kidney injury by   inhibiting JAK2/STAT3 signaling pathway in rat

赵娟

Life Sciences

2020,262:118551

SCI

47

LncRNA LINC00461   Promotes Colorectal Cancer Progression via miRNA-323b-3p/NFIB Axis

于海荣

OncoTargets and   Therapy Dovepress

2019,

12:11119-11129.

SCI

48

Effect of Hsp90   Inhibitor KW-2478 on HepG2 Cells

肖丽君

Anti-cancer agents   in medicinal Chemistry

2019,19(18):2231-2242

SCI

49

Orthohantaviruses   infections in humans and rodents in Baoji, China

郭文平

PLoS Neglected   Tropical Diseases

2020,14(10):e0008778

SCI

50

Extensive genetic   diversity of Anaplasma bovis in ruminants in Xi'an, China

郭文平

Ticks and Tick-Borne   Diseases

2020,11(5):101477

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51

Mosaic genome of   Human Coxsackievirus A4 associated with herpangina and HFMD in Yancheng,   China, 2016 and 2018

郭文平

International   Journal of Infectious Diseases

2020,96:538-540

SCI

52

An adult   co-presented with varicella and herpes zoster caused by varicella zoster   virus genotype J, China: a case report

谢广成

BMC Infectious   Diseases

2020,20(1):454

SCI

53

Annexin A5 overexpression might suppress proliferation and metastasis   of human uterine cervical carcinoma cells

李欣

Cancer Biomarkers

2018,23(1):23-32

SCI

54

AnnexinA7 down-regulation might suppress the proliferation and   metastasis of human hepatocellular carcinoma cells via MAPK/ERK pathway

李欣

Cancer Biomarkers

2018,23(4):527-537

SCI

55

Beneficial effects of combined administration of Clopidogrel and   Aspirin on the levels of proinflammatory cytokines, cardiac function,and   prognosis in ST-segment elevation myocardial infarction

于海荣

Medicine

2018,97(45):1-8

SCI

56

Downregulation of TRIM28 inhibits growth and increases apoptosis of   nude mice with non‑small cell lung cancer xenografts

刘镭

Mol Med Rep

2018,17(1):835-842

SCI

57

Dihydromyricetin induces apoptosis in a human choriocarcinoma cell   line

李玉红

Oncology Letters

2018,16(4): 4229–4234

SCI

58

Sericin enhances the insulin-Pi3K/AKT signaling pathway in the liver   of a type 2 diabetes rat model

陈志宏

Experimengtal and therapeutic medicine

2018,16(4):3345-3352

SCI



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